For more than four decades, Molecular Biology of the Cell has distilled the vast amount of scientific knowledge to illuminate basic principles, enduring concepts and cutting-edge research. The Seventh Edition has been extensively revised and updated with the latest research, and has been thoroughly vetted by experts and instructors. The classic companion text, The Problems Book, has been reimagined as the Digital Problems Book in Smartwork, an interactive digital assessment course with a wide selection of questions and automatic-grading functionality. The digital format with embedded animations and dynamic question types makes the Digital Problems Book in Smartwork easier to assign than ever before-for both in-person and online classes.

This text features lively, clear writing and exceptional illustrations, making it the ideal textbook for a first course in both cell and molecular biology. Thoroughly revised and updated, the Fifth Edition maintains its focus on the latest cell biology research. For the first time ever, Essential Cell Biology will come with access to Smartwork5, Norton's innovative online homework platform, creating a more complete learning experience.

For more than four decades, Molecular Biology of the Cell has distilled the vast amount of scientific knowledge to illuminate basic principles, enduring concepts, and cutting-edge research. The Seventh Edition has been extensively revised and updated with the latest research, and has been thoroughly vetted by experts and instructors. The classic companion text, The Problems Book, has been reimagined as the Digital Problems Book in Smartwork, an interactive digital assessment course with a wide selection of questions and automatic-grading functionality. The digital format with embedded animations and dynamic question types makes the Digital Problems Book in Smartwork easier to assign than ever before-for both in-person and online classes.

As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill this vast amount of scientific knowledge into concise principles and enduring concepts. Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in cell biology and it provides an exceptional framework for teaching and learning.

First published in 1975, Opening the Door is a survey of policies and problems in services for the mentally handicapped. It describes the improvements which have taken place since 1969, when the inquiry into conditions of patients at Ely hospital in South Wales stimulated public concern into the quality of life of many mentally handicapped people in hospital. The authors discuss the continuing gap between the idea – as laid down in the 1971 Government White Paper, Better Services for the Mentally Handicapped, which set out a blueprint for development in the 1980s that was to make the antithesis of ‘hospital’ or ‘community’ obsolete – and the reality. The study is based on detailed work in one Region by a team of staff and postgraduate students in the Department of Social Administration and Social Work at the University of York. The survey covers hospital provisions, with special attention to nursing attitudes and to problems of the ‘back wards,’ the relationship between hospitals and their surrounding communities, and the development of local authority social work and residential care services. This book will be of interest to students of social administration, social policy and health.

This major new text provides an introduction to the interaction of culture and society with the landscape and environment. It offers a broad-based view of this theme by drawing upon the varied traditions of landscape interpretation, from the traditional cultural geography of scholars such as Carl Sauer to the 'new' cultural geography which has emerged in the 1990s. The book comprises three major, interwoven strands. First, fundamental factors such as environmental change and population pressure are addressed in order to sketch the contextual variables of landscapes production. Second, the evolution of the humanised landscape is discussed in terms of processes such as clearing wood, the impact of agriculture, the creation of urban-industrial complexes, and is also treated in historical periods such as the pre-industrial, the modern and the post-modern. From this we can see the cultural and economic signatures of human societies at different times and places. Finally, examples of landscape types are selected in order to illustrate the ways in which landscape both represents and participates in social change. The authors use a wide range of source material, ranging from place-names and pollen diagrams to literature and heritage monuments. Superbly illustrated throughout, it is essential reading for first-year undergraduates studying historical geography, human geography, cultural geography or landscape history.

This guide to estimating uncertainties in the measurement, prediction and assessment of noise and vibration applies across environmental noise and vibration, occupational noise and vibration exposure, and building and architectural acoustics. The book collates information from the various Standards and from research, with explanation, examples and case studies. It enables estimation of uncertainty in the measurement and prediction of acoustic quantities, suitable for use in environmental impact and occupational exposure assessments. It is for acoustic consultants, mechanical and building service engineers, architect and building professionals and environmental health officers. Bob Peters worked for more than forty years in acoustics and noise control - teaching, research, consultancy. He was a principal acoustic consultant with Applied Acoustic Design, a senior research fellow at London South Bank University, and a tutor on Institute of Acoustics distance learning courses.

This practical guide for managers and engineers in the plastics industry shows how to reduce high noise levels which often occur in the workplace and reduce the risk of noise-induced hearing damage to employees. Practical methods for reducing noise from industrial machinery are described and illustrated with about twenty-five case studies relating to plastics processing machines such as granulators, shredders, extruders and injection moulders. Noise-control techniques include standard noise-control measures: enclosures, silencers and the use of sound insulating, sound-absorbing materials, vibration isolation and damping; and now the use of active noise control methods. Along with fresh case studies this new edition adds chapters on environmental noise, on European Union machinery noise emission regulations, hearing protection, prediction of noise levels, and the design of quieter workplaces.

This guide to estimating uncertainties in the measurement, prediction and assessment of noise and vibration applies across environmental noise and vibration, occupational noise and vibration exposure, and building and architectural acoustics. The book collates information from the various Standards and from research, with explanation, examples and case studies. It enables estimation of uncertainty in the measurement and prediction of acoustic quantities, suitable for use in environmental impact and occupational exposure assessments. It is for acoustic consultants, mechanical and building service engineers, architect and building professionals and environmental health officers. Bob Peters worked for more than forty years in acoustics and noise control - teaching, research, consultancy. He was a principal acoustic consultant with Applied Acoustic Design, a senior research fellow at London South Bank University, and a tutor on Institute of Acoustics distance learning courses.

Mathematical psychology is an interdisciplinary area of research in which methods of mathematics, operations research, and computer science in psychology are used. Now more than thirty years old, the field has continued to grow rapidly and has taken on a life of its own. This volume summarizes recent progress in mathematical psychology as seen by some of the leading figures in the field as well as some of its leading young researchers. The papers presented in this volume reflect the most important current directions of research in mathematical psychology. They cover topics in measurement, decision and choice, psychophysics and psychometrics, knowledge representation, neural nets and learning models, and cognitive modeling. Some of the major ideas included are new applications of concepts of measurement theory to social phenomena, new directions in the theory of probabilistic choice, surprising results in nonlinear utility theory, applications of boolean methods in the theory of knowledge spaces, applications of neural net ideas to concept learning, developments in the theory of parallel processing models of response time, new results in inhibition theory, and new concepts about paired associate learning.

An ideal new multi-disciplinary volume for students and scholars of philosophy, contemporary political theory, and international relations.

This volume offers key insights into the work of the chief figures in the contemporary debate surrounding thin universalism and presents a usefully themed contribution to the secondary literature on the work of Onora Oa (TM)Neill, John Rawls, Michael Walzer, Martha Nussbaum, Stuart Hampshire and others as well as a commentary on contemporary debates surrounding human rights and distributive justice. This new book enables the reader to strongly grasp all the core debates in contemporary normative theory.

An exploration of the legacy of The Waste Land on the centenary of its original publication, looking at the impact it had had upon criticism and new poetries across one hundred years. T. S. Eliot first published his long poem The Waste Land in 1922. The revolutionary nature of the work was immediately recognised, and it has subsequently been acknowledged as one of the most influential poems of the twentieth century, and as crucial for the understanding of modernism. The essays in this collection variously reflect on The Waste Land one hundred years after its original publication. At this centenary moment, the contributors both celebrate the richness of the work, its sounds and rare use of language, and also consider the poem's legacy in Britain, Ireland, and India. The work here, by an international team of writers from the UK, North America, and India, deploys a range of approaches. Some contributors seek to re-read the poem itself in fresh and original ways; others resist the established drift of previous scholarship on the poem, and present new understandings of the process of its development through its drafts, or as an orchestration on the page. Several contributors question received wisdom about the poem's immediate legacy in the decade after publication, and about the impact that it has had upon criticism and new poetries across the first century of its existence. An Introduction to the volume contextualises the poem itself, and the background to the essays. All pieces set out to review the nature of our understanding of the poem, and to bring fresh eyes to its brilliance, one hundred years on. Contributors: Rebecca Beasley, Rosinka Chaudhuri, William Davies, Hugh Haughton, Marjorie Perloff, Andrew Michael Roberts, Peter Robinson, Michael Wood.

An ideal new multi-disciplinary volume for students and scholars of philosophy, contemporary political theory, and international relations.

This volume offers key insights into the work of the chief figures in the contemporary debate surrounding thin universalism and presents a usefully themed contribution to the secondary literature on the work of Onora Oa (TM)Neill, John Rawls, Michael Walzer, Martha Nussbaum, Stuart Hampshire and others as well as a commentary on contemporary debates surrounding human rights and distributive justice. This new book enables the reader to strongly grasp all the core debates in contemporary normative theory.

Mathematical psychology is an interdisciplinary area of research in which methods of mathematics, operations research, and computer science in psychology are used. Now more than thirty years old, the field has continued to grow rapidly and has taken on a life of its own. This volume summarizes recent progress in mathematical psychology as seen by some of the leading figures in the field as well as some of its leading young researchers.
The papers presented in this volume reflect the most important current directions of research in mathematical psychology. They cover topics in measurement, decision and choice, psychophysics and psychometrics, knowledge representation, neural nets and learning models, and cognitive modeling. Some of the major ideas included are new applications of concepts of measurement theory to social phenomena, new directions in the theory of probabilistic choice, surprising results in nonlinear utility theory, applications of boolean methods in the theory of knowledge spaces, applications of neural net ideas to concept learning, developments in the theory of parallel processing models of response time, new results in inhibition theory, and new concepts about paired associate learning.

Freemasonry was a major cultural and social phenomenon and a key element of the Enlightenment. It was to have an international influence across the globe. This primary resource collection charts a key period in the development of organized Freemasonry culminating in the formation of a single United Grand Lodge of England. The secrecy that has surrounded Freemasonry has made it difficult to access information and documents about the organization and its adherents in the past. This collection is the result of extensive archival research and transcription and highlights the most significant themes associated with Freemasonry. The documents are drawn from masonic collections, private archives and libraries worldwide. The majority of these texts have never before been republished. Documents include rituals (some written in code), funeral services, sermons, songs, certificates, an engraved list of lodges, letters, pamphlets, theatrical prologues and epilogues, and articles from newspapers and periodicals. This collection will enable researchers to identify many key masons for the first time. It will be of interest to students of Freemasonry, the Enlightenment and researchers in eighteenth-century studies. Includes more than 550 texts - Many texts are published here by special arrangement with the Library and Museum of Freemasonry, London - Contains over 260 pages of newly transcribed manuscript material - Documents are organized thematically - Full editorial apparatus including general introduction, volume introductions, headnotes and explanatory endnotes - A consolidated index appears in the final volume

Freemasonry was a major cultural and social phenomenon and a key element of the Enlightenment. It was to have an international influence across the globe. This primary resource collection charts a key period in the development of organized Freemasonry culminating in the formation of a single United Grand Lodge of England. The secrecy that has surrounded Freemasonry has made it difficult to access information and documents about the organization and its adherents in the past. This collection is the result of extensive archival research and transcription and highlights the most significant themes associated with Freemasonry. The documents are drawn from masonic collections, private archives and libraries worldwide. The majority of these texts have never before been republished. Documents include rituals (some written in code), funeral services, sermons, songs, certificates, an engraved list of lodges, letters, pamphlets, theatrical prologues and epilogues, and articles from newspapers and periodicals. This collection will enable researchers to identify many key masons for the first time. It will be of interest to students of Freemasonry, the Enlightenment and researchers in eighteenth-century studies.

Freemasonry was a major cultural and social phenomenon and a key element of the Enlightenment. It was to have an international influence across the globe. This primary resource collection charts a key period in the development of organized Freemasonry culminating in the formation of a single United Grand Lodge of England. The secrecy that has surrounded Freemasonry has made it difficult to access information and documents about the organization and its adherents in the past. This collection is the result of extensive archival research and transcription and highlights the most significant themes associated with Freemasonry. The documents are drawn from masonic collections, private archives and libraries worldwide. The majority of these texts have never before been republished. Documents include rituals (some written in code), funeral services, sermons, songs, certificates, an engraved list of lodges, letters, pamphlets, theatrical prologues and epilogues, and articles from newspapers and periodicals. This collection will enable researchers to identify many key masons for the first time. It will be of interest to students of Freemasonry, the Enlightenment and researchers in eighteenth-century studies.

Freemasonry was a major cultural and social phenomenon and a key element of the Enlightenment. It was to have an international influence across the globe. This primary resource collection charts a key period in the development of organized Freemasonry culminating in the formation of a single United Grand Lodge of England. The secrecy that has surrounded Freemasonry has made it difficult to access information and documents about the organization and its adherents in the past. This collection is the result of extensive archival research and transcription and highlights the most significant themes associated with Freemasonry. The documents are drawn from masonic collections, private archives and libraries worldwide. The majority of these texts have never before been republished. Documents include rituals (some written in code), funeral services, sermons, songs, certificates, an engraved list of lodges, letters, pamphlets, theatrical prologues and epilogues, and articles from newspapers and periodicals. This collection will enable researchers to identify many key masons for the first time. It will be of interest to students of Freemasonry, the Enlightenment and researchers in eighteenth-century studies.

Freemasonry was a major cultural and social phenomenon and a key element of the Enlightenment. It was to have an international influence across the globe. This primary resource collection charts a key period in the development of organized Freemasonry culminating in the formation of a single United Grand Lodge of England. The secrecy that has surrounded Freemasonry has made it difficult to access information and documents about the organization and its adherents in the past. This collection is the result of extensive archival research and transcription and highlights the most significant themes associated with Freemasonry. The documents are drawn from masonic collections, private archives and libraries worldwide. The majority of these texts have never before been republished. Documents include rituals (some written in code), funeral services, sermons, songs, certificates, an engraved list of lodges, letters, pamphlets, theatrical prologues and epilogues, and articles from newspapers and periodicals. This collection will enable researchers to identify many key masons for the first time. It will be of interest to students of Freemasonry, the Enlightenment and researchers in eighteenth-century studies.

This major new text provides an introduction to the interaction of culture and society with the landscape and environment. It offers a broad-based view of this theme by drawing upon the varied traditions of landscape interpretation, from the traditional cultural geography of scholars such as Carl Sauer to the 'new' cultural geography which has emerged in the 1990s. The book comprises three major, interwoven strands. First, fundamental factors such as environmental change and population pressure are addressed in order to sketch the contextual variables of landscapes production. Second, the evolution of the humanised landscape is discussed in terms of processes such as clearing wood, the impact of agriculture, the creation of urban-industrial complexes, and is also treated in historical periods such as the pre-industrial, the modern and the post-modern. From this we can see the cultural and economic signatures of human societies at different times and places. Finally, examples of landscape types are selected in order to illustrate the ways in which landscape both represents and participates in social change. The authors use a wide range of source material, ranging from place-names and pollen diagrams to literature and heritage monuments. Superbly illustrated throughout, it is essential reading for first-year undergraduates studying historical geography, human geography, cultural geography or landscape history.

This second edition provides 21 new chapters on methods used in laboratories for investigating the physiology and molecular genetics of the pathogen Clostridium difficile. Chapters detail up-to -date experimental techniques for gene editing and transcriptional analysis which are used to investigate the fundamental biology of the organism and its virulence factors. Additional chapters describe development of potential new treatments including vaccines, bacteriophage and faecal transplantation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Clostridium difficile: Methods and Protocols, Second Edition provides a comprehensive catalogue of molecular tools and techniques authored by the researchers who have developed them.

This second edition provides 21 new chapters on methods used in laboratories for investigating the physiology and molecular genetics of the pathogen Clostridium difficile. Chapters detail up-to -date experimental techniques for gene editing and transcriptional analysis which are used to investigate the fundamental biology of the organism and its virulence factors. Additional chapters describe development of potential new treatments including vaccines, bacteriophage and faecal transplantation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Clostridium difficile: Methods and Protocols, Second Edition provides a comprehensive catalogue of molecular tools and techniques authored by the researchers who have developed them.

Der "kleine" Alberts gilt als das beliebteste einfuhrende Lehrbuch der Zellbiologie: wie die vierte, komplett uberarbeitete Auflage zeigt, auch vollig zu Recht. Wieder ist besonders viel Wert auf eine anschauliche Prasentation in Text und Bild gelegt worden. Ein ausgefeiltes didaktisches Konzept vereinigt Bewahrtes mit vollig Neuem:
- inklusive CD-ROM "Essential Cell Biology Interactive" mit uber 100 Video Clips, Molekulstrukturen und mikroskopischen Aufnahmen
- 20 Tafeln zu klassischen und modernen Experimenten der Biologie
- mit zwei neuen Kapiteln zu "Genetik, Meiose und die molekularen Grundlagen der Vererbung" sowie "Wie sich Gene und Genome entwickeln"
- Zusammenfassung der wichtigsten Inhalte und Schlusselbegriffe am Kapitelende
- durchgehend vierfarbige Illustrationen und ubersichtstafeln, die die grundlegenden Konzepte anschaulich darstellen
- mit uber 400 Verstandnisfragen, ubungsaufgaben und deren Losungen
- um mehr als 10 % erweitertes, illustriertes Glossar mit 600 Ausdrucken
Aus der Fulle der neuen und neuesten Erkenntnisse wurden die unentbehrlichen Grundlagen der molekularen Zellbiologie sowie ihre Anwendungen in Medizin, Gen- und Biotechnologie herausgearbeitet - ein Plus, das dieses Buch, zusammen mit seinem unverwechselbaren Stil, fur Lehrende und Lernende gleichermaen faszinierend und verlasslich macht.

Originally published in 1994, this readable and well-structured text opens with an overview of the concepts behind and advantages of blood stem cell transplants. Detailed concepts of their use are later expanded upon and critically reviewed by experts. Among the important issues discussed are hematopoietic recovery, tumor contamination and techniques used to purify stem cells. Clinical trial data follow including leukemia, lymphoma, myeloma and breast cancer. The final chapter evaluates progress in the use of blood stem cells and points possible clinical directions. This is a detailed review of the techniques in blood stem cell transplants which will be of value to anyone with an interest in the area.